Sodium Fluoride as Potential Mutagen in Mammalian Eggs

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Abstract
Evidence from other forms demonstrating mitotic chromosome damage has suggested that sodium fluoride (NaF), a primary air pollutant, be explored as a mutagenic compound in female mammalian germ cells. In vitro experiments with mouse, sheep, and cow oocytes have disclosed a low incidence of anaphase lags, suppression of polar body I, and fragmentation with rearrangement. In vivo experiments showed only a minor effect on oocyte meiotic maturation, but species’ variations of sensitivity to NaF would suggest further investigations of progeny of the ewe and cow in contaminated areas.