Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cells
- 1 April 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 290 (5805) , 368-372
- https://doi.org/10.1038/290368a0
Abstract
Ten human .lambda. light-chain-producing B lymphocytes were examined. Genes for the .kappa. constant region were deleted in each. Only 1 of the 20 possible .kappa. alleles in these cells was retained, and even this exception is rearranged. .lambda. constant region genes remain in the germ-line configuration in each of the 8 .kappa. light-chain-producing human B lymphocytes examined. A hierarchy of light-chain-gene rearrangement beginning with .kappa. and proceeding to .lambda. is suggested.This publication has 19 references indexed in Scilit:
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