Studies on the plasma membrane of normal and psoriatic keratinocytes. 5. Lectin binding

Publisher Website
Google Scholar
Abstract
The glycocalyx of epidermal keratinocytes from psoriatic patients was investigated by means of lectins. Striking changes were found in the levels of glucose and/or mannose (concanavalin A) and of N-acetylglucosamine and/or sialic acid (wheat germ agglutinin) on the surface of cells from the psoriatic lesion. Smaller but significant changes were seen in the clinically uninvolved epidermis of the patient. A marked increase in the affinity of the cell surface for Ulex europaeus agglutinin (fucose-specific) confirms previous reports of structural alterations in fucose-containing oligosaccharides in psoriasis.