Controlled Studies of Streptococcal Pharyngitis in a Pediatric Population

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Abstract
THE type-specific nature of immunity to infections A with Group A streptococci makes clinical investigation of this problem difficult. Methods for the detection of the protective antibody against the type-specific M-protein antigen1 are complex and laborious. Proper serologic identification of infecting streptococcal strains depends upon the availability of adequate amounts of typing serum and of experienced personnel trained in the exacting bacteriologic procedures. Because of the relatively slow appearance of anti-M antibody after infection2 , 3 patients must be followed for long periods despite the short duration of the streptococcal illness and its seemingly minor consequence. In addition, the widespread and often . . .