Effect of Platelet-Derived Growth Factor on the Proliferation of Blast Progenitors from Acute Myeloblastic Leukemia Patients
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 83 (4) , 187-192
- https://doi.org/10.1159/000205211
Abstract
The effect of platelet-derived growth factor (PDGF) on self-renewal and terminal divisions of blast progenitors of acute myeloblastic leukemia was studied. The terminal divisions of blast progenitors were determined as the primary blast colony formation in methylcellulose culture; self-renewal was assessed by secondary colony formation by replating in methylcellulose and the recovery of clonogenic cells in suspension culture. PDGF neither enhanced nor suppressed primary or secondary blast colony formation in methylcellulose culture nor recovery of clonogenic cells in suspension. The results show that PDGF does not affect the self-renewal or terminal divisions of leukemic blast progenitors.Keywords
This publication has 16 references indexed in Scilit:
- Proposed Revised Criteria for the Classification of Acute Myeloid LeukemiaAnnals of Internal Medicine, 1985
- The proliferation in suspension of the progenitors of the blast cells in acute myeloblastic leukemiaBlood, 1985
- PRODUCTION OF LEUKEMIC BLAST GROWTH-FACTOR BY A HUMAN BLADDER-CARCINOMA CELL-LINE1985
- Reduction of Granulocyte-Macrophage Progenitor Cells (CFU-C) and Fibroblastoid Colony-Forming Units (CFU-F) by Leukemic Cells in Human and Murine LeukemiaActa Haematologica, 1984
- Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth FactorScience, 1983
- Human Platelet-Derived Growth Factor (PDGF): Amino-Terminal Amino Acid SequenceScience, 1983
- EFFECT OF INTERFERON ON COLONY FORMATION IN CULTURE BY BLAST CELL PROGENITORS IN ACUTE MYELOBLASTIC-LEUKEMIA1980
- SEPARATION OF BLAST CELL AND LYMPHOCYTE-T PROGENITORS IN THE BLOOD OF PATIENTS WITH ACUTE MYELOBLASTIC-LEUKEMIA1979
- SELF-RENEWAL IN CULTURE OF PROLIFERATIVE BLAST PROGENITOR CELLS IN ACUTE MYELOBLASTIC-LEUKEMIA1979
- COMPARISON OF GRANULOPOIESIS IN CULTURE FROM BLOOD AND MARROW CELLS OF NONLEUKEMIC INDIVIDUALS AND PATIENTS WITH ACUTE-LEUKEMIA1976