SWR mice are resistant to collagen‐induced arthritis but produce potentially arthritogenic antibodies

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Abstract
SWR mice are resistant to collagen‐induced arthritis but produce antibodies to type II collagen. To determine if these antibodies have arthritogenic potential, serum from collagen‐immunized mice was concentrated and passively transferred to DBA/1 mice. The recipients developed severe arthritis within 72 hours. To evaluate the role of complement, SWR mice were bred with congenic inbred B10.D2/oSn (complement deficient) and B10.D2/nSn (complement normal) mice. Collagen‐immunized (SWR × B10.D2/nSn)F1 mice had high levels of C5 and were susceptible to arthritis, while (SWR × B10.D2/oSn)F1 mice were deficient in C5 and were resistant to arthritis.