A trihydroxy acyclonucleoside series
- 1 August 1984
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 62 (8) , 1622-1627
- https://doi.org/10.1139/v84-279
Abstract
An acyclonucleoside structure (Z) has been developed which possesses three hydroxymethyl groups attached to the carbon which is analogous to the 4′-carbon of natural nucleosides. The presence of the third hydroxymethyl group significantly reduces activity against herpesviruses as compared to the dihydroxymethyl (BIOLF-62) and monohydroxymethyl (acyclovir) models.This publication has 9 references indexed in Scilit:
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