Studies on .BETA.-lactam antibiotics. VIII. Structure-activity relationships of 7.BETA.-((Z)-2-carboxymethoxyimino-2-arylacetamido)-3-cephem-4-carboxylic acids.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (8) , 1068-1076
- https://doi.org/10.7164/antibiotics.38.1068
Abstract
The synthesis, antimicrobial activity and oral absorptivity of 7.beta.-[(Z)-2-carboxymethoxy-imino-2-arylacetamido]-3-cephem-4-carboxylic acids are described. The [(Z)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyimino]acetyl group was selected as the most suitable 7-substituent from seven 7-acyl groups for our further investigation of orally active cephalosporins.This publication has 4 references indexed in Scilit:
- Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. III. Synthesis and structure-activity relationships in the aminothiadiazole series.The Journal of Antibiotics, 1984
- Studies of 7.BETA.-(2-(aminoaryl)acetamido)-cephalosporin derivatives. II. Synthesis and structure-activity relationships in the aminopyrimidine series.The Journal of Antibiotics, 1984
- Studies on .BETA.-lactam antibiotics. VI. Effect on antibacterial activity of .ALPHA.-substituents in the 2-(2-amino-4-thiazolyl)acetyl side chain of a cephalosporin nucleus.The Journal of Antibiotics, 1983
- Studies on .BETA.-lactam antibiotics. VII. Effect on antibacterial activity of the oxime O-substituents with various functional groups in the 7.BETA.-((Z)-2-(2-amino-4-thiazolyl)-2-oxyiminoacetamido)cephalosporins.The Journal of Antibiotics, 1983