Effect of Fat-Loading Upon Blood Coagulation

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Abstract
The Stypven plasma clotting time provides a rough index of lipemia; hence its shortening may represent a physiologic artifact and can not be interpreted as denoting an in vivo hypercoagulable state. Such a state appears to be a common physiologic response to the (oral or intravenous) administration of fat, as reflected in shortening of the whole blood clotting time, performed with silicone technique. In certain subjects or disorders, this hypercoagulability seems to be absent or not demonstrable with the techniques used. The specific clotting factors involved, and the pathogenetic and clinical significance of these findings remain to be determined.