The metabolism of progesterone by animal tissues in vitro. 3. Investigation of the products of metabolism after incubation of 5β-pregnane-3α:20α-diol with rabbit-liver homogenate

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Abstract
In a large-scale experiment in which 5[beta]-pregnane-3[alpha]:20[alpha]-diol ("pregnanediol") was incubated with a suspension of disintegrated rabbit liver with added nicotinamide, 54% of the added steroid was accounted for by the isolation of 5[beta]-pregnane-3:20-dione (215%) and 3[alpha]-hydroxy-5[beta]-pregnan-20-one (22%) and unchanged "pregnanediol" (29%). Significance of this finding was discussed.