Spectrophotometric and Indirect Determination of Lincomycin by Atomic Absorption Spectroscopy (AAS)
- 1 June 1994
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 27 (8) , 1517-1531
- https://doi.org/10.1080/00032719408006386
Abstract
The reaction of lincomycin with cupric ions in alkaline medium was taken as a basis for the colorimetric and indirect atomic absorption spectrometric (AAS) determination of lincomycin hydrochloride. The AAS procedure was based on the extraction of copper-lincomycin complex at pH 11, into n-butanol. The copper content in this extract was determined by AAS. The response was linear for up to 30 μg ml−1 of lincomycin. The method is accurate, sensitive and simple. The proposed methods were applied to pharmaceutical preparations with fine accuracy.Keywords
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