EFFECT OF PLATELET EXTRACT ON HEMOPHILIC BLOOD

Open Access
Publisher Website
Google Scholar
Abstract
Addition of a concentrated homogenate of ground-up platelets consistently reduces the clotting times of hemophilic bloods to normal. The pro-thrombin consumption time is increased regularly, but not always significantly. These effects can be explained most satisfactorily by attributing them to the thrbmboplastic activity of the platelet prepns. When tested repeatedly over prolonged periods, hemophiliacs (in the absence of therapy) may occasionally show a normal prothrombin consumption time. The fluctuations in the clotting status may reflect variations in the patient''s ability to produce thromboplastin.