Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the national toxicology program
- 1 January 1985
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 7 (5) , 677-702
- https://doi.org/10.1002/em.2860070507
Abstract
Fifty‐three chemicals were tested for mutagenicity in Drosophila melanogaster by adult feeding and, where results were negative, by adult injection for the induction of sex‐linked recessive lethal mutations in meiotic and postmeiotic germ cell stages of Canton‐S males. One compound was tested by inhalation. Those compounds that induced lethal mutations were tested further for the induction of reciprocal translocations. Seventeen of the 53 compounds (acetaldehyde, 2‐aminoanthracene, bromoform, t‐butyl hydroperoxide, chlorambucil, trans‐cinnamaldehyde, crotonaldehyde, 1,3‐dichloro‐5,5‐dimethylhydantoin, 3,4‐dichloronitrobenzene, dimethoxane, 2,4‐dinitrotoluene, 1,2‐epoxy‐3,3,3‐trichloropropane, formaldehyde, furfural, halothane, HC yellow 4, and picric acid) were found to induce lethal mutations and three (2‐aminoanthracene, chlorambucil, and crotonaldehyde) also induced reciprocal translocations.Keywords
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