IMMUNOHISTOCHEMICAL STUDY OF ALVEOLAR AND EMBRYONAL RHABDOMYOSARCOMA

  • 1 January 1983
    • journal article
    • research article
    • Vol. 48  (2) , 148-155
Abstract
Paraffin-embedded sections of 11 alveolar and 12 embryonal rhabdomyosarcomas, 12 lymphomas, 5 neuroblastomas, 5 extraskeletal neoplasms resembling Ewing''s sarcoma, and 6 epithelial tumors were tested for immunoreactivity against myosin, myoglobin, and isozymes BB and MM of creatine kinase with a peroxidase-antiperoxidase method. Of the 23 cases of rhabdomyosarcomas 17 were positive for at least 3 of the antigenic determinants. In contrst, the other investigated tumors were consistently negative for all markers, with the exception of breast and prostatic carcinomas. The presence of 3 or 4 of the above markers in a tumor is strongly suggestive of a rhabdomyosarcoma and helpful in the distinction of alveolar and embryonal rhabdomyosarcomas from lymphomas, neuroblastomas, and extraskeletal neoplasms resembling Ewing''s sarcoma.