Gonadotropic Antiserum Effects in Normal and Irradiated Female Mice.

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Abstract
Mice 60-70 days of age were given 0.2 ml of a serum with antigonadotropic properties 5 times weekly for 6 weeks. Controls received normal rabbit serum, sheep heart antiserum, or saline. On the day of the first injection half the animals were exposed to a total body dose of 175 r. Autopsies were performed 6 weeks after irradiation. After antihormone serum treatment average ovarian and uterine weights were below controls, and there were fewer corpora lutea. The interstitial tissue of the ovaries and the uteri more frequently gave histological evidence of gonadotropic deficiency after antihormone. Irradiated and non-irradiated animals responded in an essentially similar manner, but after X-ray indications of gonadotropic deficiency were magnified. Irradiation and gonadotropic antiserum increased the gonadotropic potency of pituitary glands, neither normal rabbit serum nor sheep heart antiserum had this effect. No important differences were found in thymus weights or in adrenal or thyroid histology.