THE URINARY EXCRETION OF SUCROSE AND ITS DISTRIBUTION IN THE BLOOD AFTER INTRAVENOUS INJECTION INTO NORMAL MEN

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Abstract
When sucrose was injected intraven. into normal individuals in amts. varying from 0.06 to 1 g. per kg., the sugar excreted in the urine within 12-24 hrs. represented 89-98% of that injected. Enzymes capable of hydrolyzing sucrose were not present, either in the blood stream or in other fluids or tissues with which the sucrose might come in contact. In the individuals studied variations in the rate of excretion when small amts. of sucrose were injected were no greater than the variations observed in the sucrose clearances as detd. at different times on the same individuals. The quantity of sucrose excreted in a given time might thus be useful as an index of renal function, of the same significance as the more elaborate sucrose clearance. In 3 exps. in which creatinine was ingested before the injection of sucrose the subsequent rate of excretion of sucrose was accelerated. In the blood stream (and in vitro) sucrose penetrated the erythrocytes but slightly, if at all.