Presence of Natural Killer Cells in Specific-Pathogen-Free Chickens2
- 1 August 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 63 (2) , 527-531
- https://doi.org/10.1093/jnci/63.2.527
Abstract
Spleen cells of normal specific-pathogen-free N, P, and 15 × 7 chickens were cytotoxic In vitro for target cells of Marek's disease lymphoma line MSB-1. The natural killer (NK) cell activity, best expressed in chickens over 7 weeks old, varied among several genetic lines of chickens tested. The NK cells were thermolabile, and incubation of the cells at 37° C for 30–60 minutes resulted in substantial loss of cytotoxlcity. The specificity of NK effector cells was directed against common antigen(s) on tumor cell lines of diverse origin but not on normal adult or embryonic cells.Keywords
This publication has 5 references indexed in Scilit:
- Development of Cell-Mediated Immunity to Marek's Disease Tumor Cells in Chickens Inoculated With Marek's Disease Vaccines2JNCI Journal of the National Cancer Institute, 1978
- Status of Endogenous Avian RNA Tumor Virus in Marek's Disease Lymphoblastoid Cell Lines and Susceptibility of Those Lines to Exogenous RNA Tumor VirusesAvian Diseases, 1978
- Cell-Mediated Cytotoxic Response to Cells Bearing Marek's Disease Tumor-Associated Surface Antigen in Chickens Infected With Marek's Disease VirusJNCI Journal of the National Cancer Institute, 1977
- BCG-INDUCED MURINE EFFECTOR CELLS .2. CHARACTERIZATION OF NATURAL KILLER CELLS IN PERITONEAL EXUDATES1977
- A Nonproducer T Lymphoblastoid Cell Line from Marek's Disease Transplantable Tumor (JMV)Published by JSTOR ,1977