UPTAKE OF RADIOSULFATE IN GROWING BONES OF COCKERELS TREATED WITH CORTISONE AND CERTAIN ANABOLIC-ANDROGENIC STEROIDS

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Abstract
The effect of cortisone and certain androgenic anabolic steroids on the radiosulfate uptake by the three long bones of the young cockerel''s leg was investigated. Cortisone diminished and 17-ethyl-19-nortestosterone increased the capacity of growing bones to bind labelled sulfate. This was interpreted as a manifestation of the anti-anabolic and anabolic effect of these hormones respectively, on the synthesis of certain mucopolysaccharides of growing connective tissue, which specifically incorporate radiosulfate. The anabolic steroid 17-ethyl-19-nortestosterone counteracted the anti-anabolic effect of cortisone on growing bone, when both hormones were administered simultaneously. Neither methyl testosterone nor testosterone propionate showed any significant effect on S35 uptake by the studied bones, nor did they counteract the anti-anabolic effect of cortisone.