A Bivalent Live Virus Vaccine Against Canine Distemper (CD) and Infectious Canine Hepatitis (ICH).

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Abstract
Viru-lence of ICH virus was effectively modified by serial propagation in dog-kidney cultures followed by adaptation to and serial cultivation in swine-embryo tissue. Modified virus is an effective immunizing agent and produces in vaccinated animal no adverse reaction except for occasional light and transient opacification of the eye following massive peripheral injection of virus. Modified ICH virus may spread through urine of vaccinated animals to intimate contacts but although these develop antibodies they show no signs of disease. A combined vaccine prepared by mixing modified CD and ICH viruses elicited good protection against both diseases in doubly susceptible animals, and in puppies already immune to ICH did not interfere with production of immunity to CD.