Effects of acetylcholine infused into renal artery of dogs

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Abstract
Acetylcholine (ACh) was infused into the renal artery of nembutalized dogs. Directly measured blood flow was found to double with little if any change in arterial pressure. ACh also consistently reduced the plasma extraction ratios of paraaminohippurate (PAH), N-methylnicotinamide (NMN) and inulin (In). The supply of PAH, NMN, and inulin to the kidney increased during ACh infusion as a result of increased plasma flow. The tubular secretion of PAH and NMN increased greatly during ACh infusion at constant arterial plasma concentrations. The rate of re-moval of PAH and NMN out of the renal vein also increased. It is suggested that ACh produced a generalized vasodilatation in the kidney which increased blood flow past the PAH and NMN secretory sites.

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