Free Radical and Cytotoxic Effects of Chelators and Their Iron Complexes in the Hepatocyte
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Free Radical Research Communications
- Vol. 3 (6) , 379-388
- https://doi.org/10.3109/10715768709088079
Abstract
In a comparative screening study of chelators intended for clinical use eleven iron chelators have been tested for their ability to mobilize (59Fe) iron from 59Fe-labelled ferritin and from hepatocytes of rats labelled with 59Fe-transferrin. The toxic effects of the chelators were also studied using microsomal lipid peroxidation induced by Fe3+/ADP and NADPH. From these tests it was shown that 1,2-dimethyl 3-hydroxypyrid-4-one (L1) and mimosine were the most effective iron chelators in iron mobilization and did not catalyse lipid peroxidation. In conclusion it can be stated that besides to investigate the iron binding capacity of new chelators also their ability to catalyse lipid peroxidation has to be ruled out.Keywords
This publication has 14 references indexed in Scilit:
- Orally active α-ketohydroxy pyridine iron chelators intended for clinical use: in vivo studies in rabbitsBritish Journal of Haematology, 1986
- The study of iron mobilisation from transferrin using α-ketohydroxy heteroaromatic chelatorsBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Iron mobilization from ferritin using α-oxohydroxy heteroaromatic chelatorsBiochemical Journal, 1986
- Superoxide dismutase inhibits the superoxide‐driven Fenton reaction at two different levelsFEBS Letters, 1985
- Low-molecular-weight iron complexes and oxygen radical reactions in idiopathic haemochromatosisClinical Science, 1985
- The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidaseArchives of Biochemistry and Biophysics, 1984
- Superoxide generation by NADPH-cytochrome P-450 reductase: The effect of iron chelators and the role of superoxide in microsomal lipid peroxidationArchives of Biochemistry and Biophysics, 1984
- Reaction of iron-EDTA chelates with the superoxide radicalArchives of Biochemistry and Biophysics, 1982
- Effective Iron Chelation following Oral Administration of an Isoniazid‐Pyridoxal HydrazoneBritish Journal of Haematology, 1979
- Potential wool growth inhibitors. Improved syntheses of mimosine and related 4(1H)-PyridonesAustralian Journal of Chemistry, 1976