Separation of Organophosphonates by Ion Chromatography with Indirect Photometric Detection

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Abstract
An ion chromatographic method which utilizes lithium trimesate to separate three diphosphonate drugs and two process related organophosphonates is described. The lack of a chromophore on the five species and the high absorptivity of the trimesate anion at 254 nm allows for facile detection using indirect photometry. The effects of mobile phase concentration on the capacity factor of the species were investigated and a logarithmic relationship was established which was found to be dependent on the charge of the analyte anion and the mobile phase anion.

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