Cardiac Lesions in the Frog Induced by Adrenaline
- 1 November 1980
- journal article
- research article
- Published by Wiley in Acta Pharmacologica et Toxicologica
- Vol. 47 (5) , 359-364
- https://doi.org/10.1111/j.1600-0773.1980.tb01573.x
Abstract
Adrenaline (A) causes gross lesions of the ventricular wall in frogs living both at 12° and 25°. At 12° the sensitivity of the heart to A is higher than at 25°. Single or multiple ventricular aneurysm, provoked by A could not be prevented by propranolol. The resistance of the myocardium towards cyanide anoxia is lowered after A especially at 25°. In preliminary experiments with noradrenaline the same cardiotoxic effects are observed.Keywords
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