Optimization of parameters for maximization of plateletpheresis and lymphocytapheresis yields on the haemonetics model V50

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Abstract
Automated apheresis techniques afford the opportunity of tailoring collection parameters for each donor's hemato‐logic profile. This study investigated the effect of various settings of the volume offset parameter as utilized in the Haemonetics Model V50 instrumentation during platelet‐ and lymphocytapheresis to optimize product yield, purity, and collection efficiency. In both types of procedures, increased product yield could be obtained by using an increased volume offset for donors having lower hematocrits. This improvement was related to an increase in collection efficiency. Platelet products also contained fewer contaminating lymphocytes with this approach. Adjustment of the volume offset parameter can be utilized to make the most efficient use of donors and provide higher‐quality products.