Effects of Growth Inhibitors on Response of Rat's Uterus to Estrogen.

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Abstract
Aminopterin, beryllium, cadmium, and strychnine proved effective in reducing the physiological activity of estradiol. All compounds except strychnine effected a decrease in total nitrogen content in the uteri of ovariectomized rats receiving estradiol. Such inhibition was associated with a decrease of water in the uterine tissue and the absence of fat and glycogen. Thus, the inhibitory process is associated with these physiological changes.