Fluosol 43 particle localization pattern in target organs of rats
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Virchows Archiv
- Vol. 404 (2) , 127-137
- https://doi.org/10.1007/bf00704058
Abstract
Perfluorocarbons (PFCs), chemically inert fluorinated organic compounds with high binding capacity for O2, are under discussion as substitutes for erythrocytes. Given the paucity of E.M. observations after their use, the aim of this study was to provide more extensive ultrastructural data about PFC particle size in the emulsion and about the localization pattern in organs of rats after infusion of Fluosol 43. Attention has been focused on the particle relationships with subcellular structures and on the subsequent histopathological implications.Keywords
This publication has 19 references indexed in Scilit:
- Rapid dimensional characterization of perfluorocarbon (PFC) particles by means of EM and automatic image analysis methodsMicron and Microscopica Acta, 1983
- FDA committee questions Fluosol efficacy; US approval not imminentPublished by American Medical Association (AMA) ,1983
- Cytotoxicity of a Perfluorocarbon Blood Substitute to Macrophages in VitroScience, 1983
- Perfluorocarbon Enhancement of Heterologous Red Cell Survival: A Reticuloendothelial Block Effect?International Archives of Allergy and Immunology, 1982
- Long term experiment of perfluorochemicals using rabbitsVirchows Archiv, 1982
- Clinical Studies of A Perfluorochemical Whole Blood Substitute (Fluosol-DA)Annals of Surgery, 1982
- Effects of potential blood substitutes (Perfluorochemicals) on rat liver and spleenPflügers Archiv - European Journal of Physiology, 1980
- Fluorocarbon-Polyol Artificial Blood SubstitutesNew England Journal of Medicine, 1973
- Fluorocarbon Emulsion as a Candidate for Artificial BloodEuropean Surgical Research, 1971
- Survival of Mammals Breathing Organic Liquids Equilibrated with Oxygen at Atmospheric PressureScience, 1966