Anaerobic glycolysis of cerebral tissues and a second, electrically-induced, metabolic defect

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Abstract
Anaerobic glycolysis pro-ceeded in outer slices from the cerebral cortex of guinea pigs at about 160 [mu]moles/g/hour and in inner ones at about 130 [mu]moles/g/hour. Each rate fell about 20% after 90 minutes. The fall was more rapid in finely cut tissue; comparable rates were observed in tissue from rat and man. Electrical pulses of types which excite the brain in vitro or stimulate respiration and glycolysis aerobically in vitro decreased anaerobic glycolysis. Decreased anaerobic glycolysis persisted after pulses were stopped, and the tissue so treated lost its ability to respond aerobically to pulses, both in respiration and in glycolysis. The pres-ence of adenine or nicotinamide could partly prevent the glycolytic effect of pulses anaerobically.