THE EFFECT OF EPINEPHRINE (USP), l-EPINEPHRINE, AND l-NOREPINEPHRINE ON GLOMERULAR FILTRATION RATE, RENAL PLASMA FLOW, AND THE URINARY EXCRETION OF SODIUM, POTASSIUM, AND WATER IN NORMAL MAN 12

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Abstract
In 17 normal human subjects the intraven. admn. of epinephrine (USP), 1-epinephrine, or 1-norepinephrine at an avg. rate of 15 [mu]g. per min. depressed the urinary excretion of Na and K significantly. Since the glomerular filtration rate remained relatively constant despite elevated arterial pressure, intrarenal vasoconstriction and renal ischemia, the decreased electrolyte output has been ascribed to augmented tubular reabsorption. Urine flow usually increased slightly during the drug infusion but decreased sharply upon withdrawal, suggesting that these adrenal medullary hormones interfere with tubular water reabsorption in man.