A folate sensitive heritable fragile site at 19p13
- 23 April 2008
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 27 (5) , 510-514
- https://doi.org/10.1111/j.1399-0004.1985.tb00241.x
Abstract
A fragile site at 19p13 was found in the mother of a newborn girl with Downs syndrome. The fragile site was expressed in medium containing low folate and by addition of FdU [fluorodeoxyuridine], whereas high folate, thymidine and thymidine-analogs inhibited the expression. This fragile site may prove valuable for linkage studies on chromosome 19.Keywords
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