The Lipids in Xanthomata *

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Abstract
Lipids from venous serum of the fasting patients and the xanthomata were separated into the major neutral and phospholipid classes, and the fatty acid spectrum of each class was determined. In the phopholipids of the xanthomata, the proportion of cephalin was greater and that of lecithin smaller than in the serum. The fatty acid spectra of the triglycerides were similar in the xanthomata and serum, but in the cholesterol esters of the xanthomata oleic acid was greater (nearly 60%) and linoleic acid was less than in the serum. There was a similar but less marked difference in the phospholipids. The free fatty acids may have contained acids derived from cholesterol esters in the serum. These results and published evidence are consistent with the hypothesis that serum lipids enter xanthomata, cholesterol is retained, and the other lipids are modified or replaced by newly synthesized material so as to have a pattern in some respects similar to the lipids in other tissues.

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