THE EFFECT OF ALLOXAN DIABETES ON THE RESPONSE OF THE ADRENAL GLAND TO COLD STRESS1

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Abstract
The response of the adrenal glands of normal and diabetic rats following exposure to cold was detd. by measurement of adrenal cholesterol and ascorbic acid content. Exposure to cold, without preliminary fasting, produced a marked decrease in adrenal cholesterol in the diabetic animals. A comparable decrease was not produced in normal rats by cold unless they had been fasted previously. Cold exposure caused a decrease of adrenal ascorbic acid in both normal and diabetic rats without preliminary fasting. The response of the adrenal gland to cold, as measured by a decrease of cholesterol concn., is apparently related to curtailment of metabolically available carbohydrate.