Sex Difference in the Transport of p-Aminohippurate by the Rat Kidney1

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Abstract
Experiments were done to determine whether a significant difference exists in the ability of male and female rat kidneys to transport p-aminohippurate (PAH). The rate of transport of PAH, as measured in renal cortical slices and in intact kidneys from unanesthetized, undisturbed rats, was approximately 50% higher in males than in females. Gonadectomy abolished the sex difference and administration of testosterone to gonadectomized rats increased the rate of PAH transport.