Absorption and Metabolism of Ruelene by Arthropods1

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Abstract
The absorption and metabolism of P32-labeled Ruelene® (O-4-tert-butyl-2-chlorophenyl O-methyl methylphosphoramidate) was studied in 16 species of arthropods. The house fly, Musca domestica L.; stable fly, Stomoxys calcitrans (L.); yellow meal-worm, Tenebrio molitor L.; and American cockroach,Periplaneta americana (L.), absorbed greater than 80% of the topically applied dose by 24 hours after treatment, whereas the boll weevil, Anthonomus grandis Boheman; Gulf Coast tick, Amblyomma maculatum and brown dog tick, Rhipicephalus sanguineus (Latreille), absorbed less than 2.5% of the applied dose. In general, adult Diptera degraded Ruelene more completely than Lepidoptera larvae, adult Coleoptera, or adult Hemiptera. Most of the radioactivity in the acetone extract of insects had the same Rf as Ruelene. The metabolism of Ruelene by insects and ticks was less complex than in mammals. Selectivity was probably a function of absorption and detoxification rates in naturally tolerant and in susceptible arthropod species.