EFFECTS OF PYRAZINOATE AND PARA-AMINOHIPPURATE ON RENAL URATE EXCRETION BY THE DOG AND GUINEA-PIG

  • 1 January 1983
    • journal article
    • research article
    • Vol. 224  (2) , 364-368
Abstract
In anesthetized dogs, pyrazinoate reduced the fractional excretion of urate when the concentration of the drug in plasma ranged from 3 to 300 .mu.g/ml. At higher concentrations, fractional excretion rose progressively. p-Aminohippurate at concentrations in plasma ranging from 1 to 1000 .mu.g/ml had no effect on the fractional excretion of urate. In guinea pigs, pyrazinoate exerted only a faint uricosuric action and p-aminohippurate was without effect. Both substances were tested over the range of 1-1000 .mu.g/ml of plasma. The results in dogs help explain some previous reports of negative experiments with pyrazinoate; the doses used were not optimal for detecting responses. Urate secretion in the guinea pig evidently does not fit either of 2 previously recognized mechanisms.

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