Effect of hormones on fatty acid release by rat adipose tissue in vivo

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Abstract
A method is described for studying in vivo fatty acid release in the rat parametrial fat body. Fatty-acid release was accelerated by fasting and by "total" pancreatectomy. Injection of insulin increased fatty-add release in fasted normal rats and decreased release in pancreatectomized rats. The lipolytic effect of insulin in normal rats occurred even when the blood glucose was maintained above 200 mg/100 ml Glncagon infusion increased fatty-acid release in insulin-treated pancreatectomized rats. The findings suggest that insulin may stimulate in normal rats secretion of glucagon or some other pancreatic factor which can cause release of fattty-acids in the presence of insulin. Injection of growth hormone and dexamethasone together accelerated fatty-acid release in fasted normal rats; the effect on fatty-acid release occurred 1 hr. after injection and was followed 2 hr. later by an increase in blood ketone bodies. Injection of adrenocorticotropic hormone (ACTH) increased immediately fatty-acid release in fed normal rats.

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