THE SIGNIFICANCE OF THE ADENOHYPOPHYSIS, ADRENAL CORTEX AND THYROID IN RENAL FUNCTION IN MAN

Publisher Website
Google Scholar
Abstract
Three patients with postpartum panhypopituitarism, 6 with chromophobe adenoma of the pituitary, 8 with acromegaly, 7 with adrenocortical insufficiency and one with spontaneous myxedema were studied by inulin and diodrast clearance technics. In hypopituitarism and chromophobe adenoma, the renal plasma flow (RPF) and glomerular filtration rate (GFR) were reduced, but the filtration fraction (FF) remained normal. Desoxycorticosterone increased GFR but not RPF; thyroxin increased RPF. Combined therapy improved both, but not to normal levels. Function studies were normal in all acromegalic patients except 1 with concomitant adrenocortical insufficiency, where GFR was reduced. In adrenocortical insufficiency, GFR was reduced relatively more than RPF, so that FF was also reduced. Desoxycorticosterone acetate and NaCl increased GFR without affecting RPF. In myxedema, both GFR and RPF were reduced. Thyroxin produced only partial restoration. Failure of treatment to restore function to normal may have been due to lack of growth hormone; however, it may have been a result of the short duration of treatment.
Keywords