Effects of Epinephrine and l-Nor-Epinephrine on Renal Excretion of Solutes During Mannitol Diuresis in the Hydropenic Dog

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Abstract
Electrolyte excretion and hemodynamics were measured in 12 dogs in which osmotic diuresis was induced in hydropenia by intraven. infusion of hypertonic mannitol. Epinephrine produced a diminution in the urinary concns. of Na and Cl as well as in filtration rate and renal plasma flow. 1-Norepinephrine produced minor changes in electrolyte excretion and in hemodynamics. Epinephrine appeared to exert effects on both the intraglomerular and extraglomerular portions of the nephron.