Renal Excretion of Calcium and Phosphorus in Pseudohypoparathyroidism

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Abstract
Following 4-hr intravenous infusion of calcium in a patient with pseudohypoparathyroidism, 24-hr urinary excretion of phosphorus increased, a response common in hypoparathyroidism. Clearance studies 12 hr after termination of the infusion showed a decrease in renal tubular reabsorption of phosphate from control levels when a total of 2400 U of parathyroid extract had been given during the 3 days preceding the loading test. Intravenous phosphate loading failed to increase tubular reabsorption of phosphate above control levels, but did induce a decrease in serum calcium and an increase in urinary calcium excretion. Chronic administration of parathyroid extract alone had no effect on the tubular reabsorption of phosphate or on the response to phosphate infusion, but it did increase the serum calcium concentration temporarily.