PREFERENTIAL SITES OF GROWTH OF HUMAN-TUMORS IN NUDE-MICE FOLLOWING SUBCUTANEOUS TRANSPLANTATION

  • 1 January 1980
    • journal article
    • research article
    • Vol. 40  (12) , 4509-4511
Abstract
The growth characteristics and biological behavior of human tumors transplanted s.c. into 2 anatomical regions of nude mice were studied. Tumors transplanted in the anterior lateral thoracic wall grew faster than did tumors transplanted in the posterior aspect of the trunk. Anteriorly growing tumors, in contrast to the posteriorly transplanted ones, were better vascularized, showed less necrosis, invaded the tumor bed and metastasized to the regional lymph nodes. These findings were independent of their histogenetic and morphological characteristics. Regional vascular supply is a key factor influencing the biological behavior of the transplanted tumors and it may affect tumor response to treatment as well.