Evaluation of the Protein Anabolic Properties of Certain Orally Active Anabolic Agents Based on Nitrogen Balance Studies in Rats1

Publisher Website
Google Scholar
Abstract
The anabolic and androgenic properties of steroids of clinical interest were evaluated in multiple dose level studies. The anabolic estimates were arrived at on the basis of nitrogen balance studies; the androgenic activities were based on the increase in weight of the ventral prostate gland of the immature rat following a 10-day dosage regimen. A summary of the anabolic activity based on the ability to support nitrogen retention, the androgenic activity, and the ratio of the two (estimates +SE) is given in Table 1, which shows that isoxazole conjugation duplicated pyrazole conjugation importantly in separating the desired anabolic activity from the unwanted masculinizing activity of methy landrostanolone.