EFFECT OF NOCARDIA-RUBRA CELL-WALL SKELETON ON THE INDUCTION OF LUNG-CANCER IN ACI-N RATS
- 1 January 1979
- journal article
- research article
- Vol. 70 (1) , 55-+
Abstract
In ACI/N rats administration of oil-attached N. rubra cell-wall skeleton (CWS) was evaluated for its effect on lung cancer induction. Lung cancers were induced by 15 weekly intratracheal instillations of 3 mg benzo[a] pyrene with 3 mg ferric oxide. After the 10th instillation of the carcinogen, rats received 7 s.c. injections of 100 .mu.g of N. rubra-CSW at 2 wk intervals. In the observation period of 56 wk, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.This publication has 9 references indexed in Scilit:
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