Effects of Chronic Growth Hormone Treatment on Lipogenesis by Rat Adipose Tissue

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Abstract
Treatment of hypophysectomized rats with ovine growth hormone (1 mg /rat/day for 4 days) results in a decrease in the ether-extractable material in both epididymal and omental adipose tissue. Concomitantly, the ability of adipose tissue obtained from these animals to synthesize lipid in vitro from uniformly labeled glucose or leucine-2-C14 is reduced by a factor of at least 3. The oxidation of glucose to CO2 is also reduced, but the formation of CO2 from leucine is unaffected. It is suggested that inhibition of lipid synthesis may be causally related to many of the previously noted effects of growth hormone on lipid metabolism.