The persistence in the blood stream of some compounds related to suramin

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Abstract
The persistence of suramin (Germanin, Bayer 205) and 11 related compounds in the blood of rabbits has been investigated following intraven. injn. of 100 mg./kg. Methods for determining each of the 12 compounds are described. Marked persistence is a property of polyamides of high mol. wt. that contain naphthylamine-polysulphonic acids as end groups. Carboxylic acids of similar molecular complexity are eliminated more rapidly. There is no relation between persistence and therapeutic activity. Suramin is probably not hydrolyzed in vivo.

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