LIVER FUNCTION, PULSE RATE AND TEMPERATURE OF HYPERTHYROID DOGS

Abstract
A yeast-free diet renders dogs extremely susceptible to the effects of thyroid feeding, an abnormal liver function being produced in an avg. of 22 days, and with a small amt. of yeast in 45 days; with a high B vit. diet it took 90 days. A high B vit. diet delays but does not prevent the appearance of an abnormal liver function in hyperthyroid -dogs. On a yeast-free diet such dogs develop only slight tachycardia which returns to normal within 10 days. Without thiamine thyroid feeding does not produce tachycardia. Hyperthyroid dogs receiving a high B vit. diet maintained a high pulse rate for 80-100 days of thyroid feeding; thereafter the pulse rate fell toward normal, the fall seeming to be correlated with compensatory hypertrophy of the heart. The relation of these changes to those seen in Graves'' disease is discussed.