EXCRETION OF FOLLICLE STIMULATING HORMONE AND INTERSTITIAL-CELL STIMULATING HORMONE IN DIFFERENT PHASES OF THE NORMAL MENSTRUAL CYCLE*

Publisher Website
Google Scholar
Abstract
Extracts from pools of human follicular-phase urine and pools of mid-cycle urine were compared for relative FSH and ICSH content by determining the ratio of testes weight to ventral prostate weight in hypophysectomized immature male rats. In a pilot study utilizing purified animal pituitary extracts, pituitary FSH was found to produce a significantly higher testicular-ventral prostate ratio as compared to that produced by pituitary LH. In 2 of 3 pairs of experiments there was a statistical difference in the mean regression lines produced by the extracts of mid-cycle urine as compared to those produced by follicular-phase urine. In the third experiment a trend in the same direction was noted although it could not be said that the difference was statistically significant. It was concluded that there was a qualitative difference in urinary gonadotropin excretion in the two phases of the menstrual cycle studied.