Effect of Urinary “Gonadotrophin-inhibiting Substance” Upon the Action of Human Chorionic Gonadotrophin (APL) and on Human Postmenopausal Urinary Gonadotrophin (Pergonal)

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Abstract
The studies described in this paper demonstrate that the gonadotrophininhibiting substance present in urine of normal subjects inhibits urinary gonadotrophin exercising an LH-like effect (APL), while such inhibition is absent with gonadotrophin manifesting FSH-like action (Pergonal). Data are presented to establish the physiologic character of this fraction.

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