PROBLEMS RELATED TO THE ADMINISTRATION OF ACTH

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Abstract
Intermittent intramusc. injns. of ACTH were given to 17 patients with rheumatic diseases, and the response of 17-ketosteroids, neutral reducing lipids (both in urine) and blood eosinophils was followed. The clinical and hormonal response was increased after increasing the dose in a single injn. No "ceiling" could be found for this effect. Subdividing a given dose into many injns. increased its effectiveness. Six daily doses are more effective than 3. For practical purposes, a slowly-absorbed prepn. is desirable. ACTH in tragacanth was no better than aqueous ACTH, but ACTH in 25% poly-vinylpyrrolidone was more effective than aqueous in 1 of 2 cases.