Effects of Saline Load, Roentgen Contrast Medium and Indomethacin on Diuresis and Pelvic Pressure in the Acute Obstructed Kidney

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Abstract
In anesthetized pigs indomethacin (2.5 mg/kg body wt) immediately reduced pelvic pressure above unilaterally and bilaterally totally occluded ureters. Repeated administration of the same dose caused a cumulative reduction of pelvic pressure. In animals with a kidney working against a partial obstruction of the ureter, indomethacin reduced urine production by > 50% within 15-30 min. The effect of indomethacin on the pelvic pressure was dependent on fluid load of the animals. Rapid infusion of saline or X-ray contrast medium counteracted the pressure fall induced by indomethacin.