Mode of action of vitamin D. The effect of vitamin D deficiency in the rat on anaerobic glycolysis and pyruvate oxidation by epiphyseal cartilage

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Abstract
Anaerobic breakdown of glycogen and phosphorylated hexoses and the oxidation of pyruvate by epiphyseal cartilage of the tibiae of rats kept on rachitogenic diets with and without vitamin D was studied by the Warburg manometric technique. In rachitic rats the glycolytic activity of the epiphyseal cartilage was almost the same as that observed in vitamin D protected rats in comparable experiments. In well established rickets the epiphyseal cartilage of the rat loses the capacity to oxidize pyruvate. The significance of the above findings in the mechanism of calcification was discussed.