Rapid Diagnosis of Measles from Urinary Sediments Stained with Fluorescent Antibody

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Abstract
SEVERAL acute systemic viral illnesses have been associated with the presence of multinucleated giant cells or inclusion-bearing cells (or both) detected in nasal discharges1 and specimens of urine in human patients.2 3 4 5 6 7 Such cells have also been observed in the urinary sediments of children vaccinated with poliovirus and measles.3 , 8 Nevertheless, conclusive evidence that these cytologic changes are directly related to viral infections is still lacking. Others have reported the application of the fluorescent-antibody staining technic, to demonstrate viral antigens in clinical specimens whereby specific diagnosis can be made in infections caused by influenza,9 , 10 rabies,11 herpes simplex12 and infections with Coxsackie virus . . .

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